Desorption–ionization mass spectrometry on porous silicon

@article{Wei1999DesorptionionizationMS,
  title={Desorption–ionization mass spectrometry on porous silicon},
  author={Jing Wei and J. Buriak and G. Siuzdak},
  journal={Nature},
  year={1999},
  volume={399},
  pages={243-246}
}
Desorption mass spectrometry has undergone significant improvements since the original experiments were performed more than 90 years ago. The most dramatic change occurred in the early1980s with the introduction of an organic matrix,, to transfer energy to the analyte. This reduces ion fragmentation but also introduces background ions from the matrix. Here we describe a matrix-free strategy forbiomolecular mass spectrometry based on pulsed-laser desorption–ionization from a porous silicon… Expand
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