Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype.

  title={Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype.},
  author={Maryam Ahmadian and Marcia J Abbott and Tianyi Tang and Carolyn S. S. Hudak and Yangha Kim and Matthew D Bruss and Marc K. Hellerstein and Hui-Young Lee and Varman T Samuel and Gerald I Shulman and Yuhui Wang and Robin E. Duncan and Chulho Kang and Hei Sook Sul},
  journal={Cell metabolism},
  volume={13 6},
While fatty acids (FAs) released by white adipose tissue (WAT) provide energy for other organs, lipolysis is also critical in brown adipose tissue (BAT), generating FAs for oxidation and UCP-1 activation for thermogenesis. Here we show that adipose-specific ablation of desnutrin/ATGL in mice converts BAT to a WAT-like tissue. These mice exhibit severely impaired thermogenesis with increased expression of WAT-enriched genes but decreased BAT genes, including UCP-1 with lower PPARα binding to its… CONTINUE READING
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