Desmosterol may replace cholesterol in lipid membranes.

  title={Desmosterol may replace cholesterol in lipid membranes.},
  author={Daniel Huster and Holger A. Scheidt and Klaus Arnold and Andreas Herrmann and Peter M{\"u}ller},
  journal={Biophysical journal},
  volume={88 3},
Recently, knockout mice entirely lacking cholesterol have been described as showing only a mild phenotype. For these animals, synthesis of cholesterol was interrupted at the level of its immediate precursor, desmosterol. Since cholesterol is a major and essential constituent of mammalian cellular membranes, we asked whether cholesterol with its specific impact on membrane properties might be replaced by desmosterol. By employing various approaches of NMR, fluorescence, and EPR spectroscopy, we… CONTINUE READING

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