Desmosterol may replace cholesterol in lipid membranes.

@article{Huster2005DesmosterolMR,
  title={Desmosterol may replace cholesterol in lipid membranes.},
  author={Daniel Huster and Holger A. Scheidt and Klaus Arnold and Andreas Herrmann and Peter M{\"u}ller},
  journal={Biophysical journal},
  year={2005},
  volume={88 3},
  pages={1838-44}
}
Recently, knockout mice entirely lacking cholesterol have been described as showing only a mild phenotype. For these animals, synthesis of cholesterol was interrupted at the level of its immediate precursor, desmosterol. Since cholesterol is a major and essential constituent of mammalian cellular membranes, we asked whether cholesterol with its specific impact on membrane properties might be replaced by desmosterol. By employing various approaches of NMR, fluorescence, and EPR spectroscopy, we… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Universal behavior of membranes with sterols.

Biophysical journal • 2006
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Generation of viable cholesterol-free mice.

Science • 2003
View 4 Excerpts
Highly Influenced

Functional rafts in cell membranes

Nature • 1997
View 4 Excerpts
Highly Influenced

Differential effects of cholesterol and lanosterol on artificial membranes.

Proceedings of the National Academy of Sciences of the United States of America • 1977
View 5 Excerpts
Highly Influenced

Use of the spin label tempamine for measuring the internal viscosity of red blood cells

P. D. Morse
Biochem. Biophys. Res. Commun. 77:1486–1491. • 1977
View 1 Excerpt
Highly Influenced

Similar Papers

Loading similar papers…