Desmosterol in human nonalcoholic steatohepatitis.

  title={Desmosterol in human nonalcoholic steatohepatitis.},
  author={Marko Simonen and Ville M{\"a}nnist{\"o} and Joel Lepp{\"a}nen and Dorota Kaminska and Vesa J K{\"a}rj{\"a} and Sari VenesmaaSari Venesmaa and Pirjo K{\"a}kel{\"a} and Johanna Kuusisto and H Gylling and Markku Laakso and Jussi Pihlajam{\"a}ki},
  volume={58 3},
UNLABELLED Dysregulation of the cholesterol synthesis pathway and accumulation of cholesterol in the liver are linked to the pathogenesis of nonalcoholic steatohepatitis (NASH). Therefore, we investigated the association of serum and liver levels of cholesterol precursors with NASH. Liver histology was assessed in 110 obese patients (Kuopio Obesity Surgery Study [KOBS] study, age 43.7 ± 8.1 years [mean ± standard deviation, SD], body mass index [BMI] 45.0 ± 6.1 kg/m(2) ). Serum and liver levels… CONTINUE READING
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