Desmosomes and disease: an update.

  title={Desmosomes and disease: an update.},
  author={Martyn Chidgey},
  journal={Histology and histopathology},
  volume={17 4},
Desmosomes play a critical role in the maintenance of normal tissue architecture. Skin blistering can occur when desmosomal adhesion is compromised by antibodies in autoimmune diseases such as pemphigus. Inherited mutations in genes encoding desmosomal constituents can adversely affect the skin, and result in heart abnormalities. Desmosomes may have a tumour suppressor function: expression of desmosomal components is reduced in some human cancers, and desmosomal cadherins have the capacity to… CONTINUE READING
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  • M. Deguchi, L. Ribeiro-Filho, R. Dahiya
  • 2001

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