Desmosomes: adhesive strength and signalling in health and disease.

  title={Desmosomes: adhesive strength and signalling in health and disease.},
  author={Helen A. Thomason and Anthea Scothern and Selina McHarg and David R. Garrod},
  journal={The Biochemical journal},
  volume={429 3},
Desmosomes are intercellular junctions whose primary function is strong intercellular adhesion, known as hyperadhesion. In the present review, we discuss how their structure appears to support this function as well as how they are assembled and down-regulated. Desmosomal components also have signalling functions that are important in tissue development and remodelling. Their adhesive and signalling functions are both compromised in genetic and autoimmune diseases that affect the heart, skin and… CONTINUE READING