Desmosome assembly and disassembly are regulated by reversible protein phosphorylation in cultured epithelial cells.

@article{Pasdar1995DesmosomeAA,
  title={Desmosome assembly and disassembly are regulated by reversible protein phosphorylation in cultured epithelial cells.},
  author={Manijeh Pasdar and Zhi Li and H Chan},
  journal={Cell motility and the cytoskeleton},
  year={1995},
  volume={30 2},
  pages={
          108-21
        }
}
Desmosomes are one component of the intercellular junctional complex in epithelia. In cultures of epithelial cells, desmosome assembly can be regulated by modulating the calcium concentrations of the growth media. At present, very little is known about the intracellular signal transduction mechanisms that regulate desmosome assembly and disassembly in response to changing extracellular calcium concentrations. We have used inhibitors of protein kinases and phosphatases in a combined biochemical… CONTINUE READING
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