Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice.

@article{Bierkamp1999DesmosomalLO,
  title={Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice.},
  author={Christiane Bierkamp and Heinz J. Schwarz and Otmar Huber and Rolf Kemler},
  journal={Development},
  year={1999},
  volume={126 2},
  pages={371-81}
}
Plakoglobin, a protein belonging to the Armadillo-repeat gene family, is the only component that adherens junctions and desmosomes have in common. Plakoglobin null-mutant mouse embryos die because of severe heart defects and may exhibit an additional skin phenotype, depending on the genetic background. Lack of plakoglobin affects the number and structure of desmosomes, resulting in visible defects when cells are subjected to increasing mechanical stress, e.g. when embryonic blood starts… CONTINUE READING

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