Desmosomal adhesion regulates epithelial morphogenesis and cell positioning

  title={Desmosomal adhesion regulates epithelial morphogenesis and cell positioning},
  author={Sarah K. Runswick and Mike J. O'Hare and Louise Jones and Charles H Streuli and David R. Garrod},
  journal={Nature Cell Biology},
Desmosomes are intercellular junctions of epithelia and are of widespread importance in the maintenance of tissue architecture. We provide evidence that desmosomal adhesion has a function in epithelial morphogenesis and cell-type-specific positioning. Blocking peptides corresponding to the cell adhesion recognition (CAR) sites of desmosomal cadherins block alveolar morphogenesis by epithelial cells from mammary lumen. Desmosomal CAR-site peptides also disrupt positional sorting of luminal and… CONTINUE READING


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Desmosome biogenesis in the mouse preimplantation NATURE CELL BIOLOGY VOL 3 SEPTEMBER 2001

  • T. P. Fleming, D. R. Garrod, A. J. Elsmore
  • Macmillan Magazines Ltd articles NATURE CELL…
  • 2001

Integrin Protocols (Methods in Molecular Biology

  • G. M. Edwards, C. H. Streuli
  • New Jersey,
  • 1999

Laminin and β1 integrins are crucial for normal mammary gland development in the mouse

  • Klinowska, M T.C.
  • Dev. Biol
  • 1999

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