Desmopressin: therapeutic limitations in children and adults with inherited coagulation disorders.

@article{Nolan2000DesmopressinTL,
  title={Desmopressin: therapeutic limitations in children and adults with inherited coagulation disorders.},
  author={Beatrice Nolan and Benajmin White and Judith K. Smith and C O'Reily and Barb Fitzpatrick and Owen Patrick Smith},
  journal={British journal of haematology},
  year={2000},
  volume={109 4},
  pages={865-9}
}
Desmopressin (DDAVP), a synthetic analogue of vasopressin has been successfully used in the treatment of type I von Willebrand's disease (VWD), mild factor VIII (FVIII) deficiency and intrinsic platelet function defects (PFDs) for almost three decades. However, there is limited published data documenting its efficacy and the reliability of circulating plasma FVIII:C as a surrogate marker of response to therapy in VWD. We report the haemostatic response to DDAVP in 133 consecutive patients (91… CONTINUE READING