Desmoplastic infantile astrocytoma and ganglioglioma: a search for genomic characteristics

@article{Kros2002DesmoplasticIA,
  title={Desmoplastic infantile astrocytoma and ganglioglioma: a search for genomic characteristics},
  author={Johan M. Kros and Ernst J. Delwel and Rob T. de Jong and Herve L. J. Tanghe and Peter R. van Run and Kees Vissers and Janneke C. Alers},
  journal={Acta Neuropathologica},
  year={2002},
  volume={104},
  pages={144-148}
}
In the present study the clinical data, histology, proliferation rate, DNA ploidy status and the results of TP53 mutation analysis and comparative genomic hybridization (CGH) of three typical cases of desmoplastic infantile astrocytoma and ganglioglioma are presented. Postoperative disease-free intervals of 11, 8 and 3 years were recorded and in none of the cases were radiological signs of tumor recurrence. No TP53 mutations (exons 5–8) were found. CGH analysis revealed loss of 8p22-pter in one… CONTINUE READING