Desmoplakin is essential in epidermal sheet formation

  title={Desmoplakin is essential in epidermal sheet formation},
  author={Valeri Vasioukhin and E. Bowers and Christoph Bauer and Linda C Degenstein and Elaine Fuchs},
  journal={Nature Cell Biology},
We have generated an epidermis-specific desmoplakin (DP) mouse knockout, and show that epidermal integrity requires DP; mechanical stresses to DP-null skin cause intercellular separations. The number of epidermal desmosomes in DP-null skin is similar to wild type (WT), but they lack keratin filaments, which compromise their function. DP-null keratinocytes have few desmosomes in vitro, and are unable to undergo actin reorganization and membrane sealing during epithelial sheet formation. Adherens… CONTINUE READING
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