Desmoglein Endocytosis and Desmosome Disassembly Are Coordinated Responses to Pemphigus Autoantibodies*

@article{Calkins2006DesmogleinEA,
  title={Desmoglein Endocytosis and Desmosome Disassembly Are Coordinated Responses to Pemphigus Autoantibodies*},
  author={C. C. Calkins and S. Setzer and J. M. Jennings and S. Summers and K. Tsunoda and M. Amagai and A. Kowalczyk},
  journal={Journal of Biological Chemistry},
  year={2006},
  volume={281},
  pages={7623 - 7634}
}
Desmosomes are adhesive intercellular junctions prominent in the skin and heart. Loss of desmosome function is associated with severe congenital and acquired disorders characterized by tissue fragility. Pemphigus vulgaris (PV) is an autoimmune disorder in which antibodies are directed against the desmosomal adhesion molecule Dsg3, resulting in severe mucosal erosions and epidermal blistering. To define the mechanisms by which Dsg3 autoantibodies disrupt keratinocyte adhesion, the fate of PV IgG… Expand
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