Desmin Is Essential for the Tensile Strength and Integrity of Myofibrils but Not for Myogenic Commitment, Differentiation, and Fusion of Skeletal Muscle

@article{Li1997DesminIE,
  title={Desmin Is Essential for the Tensile Strength and Integrity of Myofibrils but Not for Myogenic Commitment, Differentiation, and Fusion of Skeletal Muscle },
  author={Zhenlin Li and Mathias Mericskay and Onnik Agbulut and Gillian Butler-Browne and Lena Carlsson and Lars-Eric Thornell and Charles Babinet and Denise Paulin},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={139},
  pages={129 - 144}
}
A null mutation was introduced into the mouse desmin gene by homologous recombination. The desmin knockout mice (Des -/-) develop normally and are fertile. However, defects were observed after birth in skeletal, smooth, and cardiac muscles (Li, Z., E. Colucci-Guyon, M. Pincon-Raymond, M. Mericskay, S. Pournin, D. Paulin, and C. Babinet. 1996. Dev. Biol. 175:362-366; Milner, D.J., G. Weitzer, D. Tran, A. Bradley, and Y. Capetanaki. 1996. J. Cell Biol. 134:1255- 1270). In the present study we… CONTINUE READING
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