Desmethionine alkylamide bombesin analogues: a new class of bombesin receptor antagonists with potent antisecretory activity in pancreatic acini and antimitotic activity in Swiss 3T3 cells.

@article{Wang1990DesmethionineAB,
  title={Desmethionine alkylamide bombesin analogues: a new class of bombesin receptor antagonists with potent antisecretory activity in pancreatic acini and antimitotic activity in Swiss 3T3 cells.},
  author={Lei Wang and David H. Coy and John Ellor Taylor and N-Y. Jiang and Sung Ho Kim and Jacques Pierre Moreau and Sui Huang and Samuel A. Mantey and Harold A. Frucht and Robert Thomas Jensen},
  journal={Biochemistry},
  year={1990},
  volume={29 3},
  pages={
          616-22
        }
}
Bombesin-related peptides have a large number of physiological functions as well as having an autocrine growth mechanism for the regulation of small cell lung cancer cells. In the present study we have synthesized 21 des-Met amide or alkylamide analogues of bombesin and compared their abilities to function as bombesin receptor antagonists in guinea pig pancreatic acini and Swiss 3T3 cells with those of the previously most potent antagonist described, [Leu13 psi(CH2NH)Leu14]bombesin (analogue I… CONTINUE READING
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