Desirudin reduces the rate of microvenous thrombosis in a rat model.


OBJECTIVES In an effort to evaluate pharmacologic agents for optimal anticoagulant prophylaxis in patients undergoing free tissue transfer, we evaluated the efficacy of desirudin (Canyon Pharmaceuticals, Hunt Valley, MD), a recombinant hirudin that acts as a direct thrombin inhibitor, using a rat model of microvenous thrombosis. STUDY DESIGN Randomized… (More)
DOI: 10.1097/MLG.0b013e31816d727c


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