Desipramine treatment reduces the long-term behavioural and neurochemical sequelae of early-life maternal separation.

@article{MacQueen2003DesipramineTR,
  title={Desipramine treatment reduces the long-term behavioural and neurochemical sequelae of early-life maternal separation.},
  author={Glenda M. MacQueen and Karuna Ramakrishnan and Ravena Ratnasingan and Biao Chen and Lionel Trevor Young},
  journal={The international journal of neuropsychopharmacology},
  year={2003},
  volume={6 4},
  pages={391-6}
}
Primate and rodent models of maternal separation have shown that repeated postnatal separation of young from the mother results in long-term changes to neurohormonal systems relevant to depression. To date, however, it remains unclear whether rodents that experience postnatal maternal separation display specific behavioural or biochemical features of depression in adulthood and whether these changes can be prevented by treatment with antidepressant drugs. We report here that maternally… CONTINUE READING