Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress.

@article{Xie2017DesipramineRA,
  title={Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress.},
  author={Xiaoxian Xie and Yangyang Chen and Qi Wang and Qichen Shen and Lingyan Ma and Liangfeng Huang and Tao Wu and Zhengwei Fu},
  journal={Life sciences},
  year={2017},
  volume={188},
  pages={
          96-100
        }
}
AIMS Our previous finding demonstrates that major depressive disorder can mediate accelerated aging in rats. Desipramine is a typical tricyclic antidepressant, and can provide neuroprotection and counteract depression-like behaviors. However, whether desipramine can rescue age-related phenotypes in depressed individuals is not understood. In the present study, we investigated the physiological function of desipramine on rescuing the age-related phenotypes in these animals. MAIN METHODS The… CONTINUE READING
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