Desipramine relieves postherpetic neuralgia.

  title={Desipramine relieves postherpetic neuralgia.},
  author={R Kishore-Kumar and Mitchell B. Max and Susan C. Schafer and A M Gaughan and Bruce S Smoller and Richard H. Gracely and Ronald Dubner},
  journal={Clinical pharmacology and therapeutics},
  volume={47 3},
Desipramine has the least anticholinergic and sedative effects of the first generation tricyclic antidepressant agents, but its pain-relieving potential has received little study. Other antidepressant agents--notably amitriptyline--are known to ameliorate postherpetic neuralgia, but those agents are often toxic. In a randomized double-blind crossover design, we gave 26 postherpetic neuralgia patients 6 weeks of treatment with desipramine (mean dose, 167 mg/day) and placebo. Nineteen patients… CONTINUE READING


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