Desipramine pharmacokinetics in Chinese and Caucasian volunteers.

  title={Desipramine pharmacokinetics in Chinese and Caucasian volunteers.},
  author={Matthew V. Rudorfer and Elizabeth A. Lane and W- H Chang and Mainul Huq David Wheeler Chonghua Zhang and William Z. Potter},
  journal={British journal of clinical pharmacology},
  volume={17 4},
In order to better define the role of pharmacokinetic variation in reported cross-ethnic differences in dosing patterns of some psychoactive drugs, single dose kinetics of the tricyclic antidepressant desipramine (DMI) were studied in 14 Chinese and 16 Caucasian healthy volunteers. DMI and 2-OH-DMI concentrations were assayed with h.p.l.c. in serial plasma and 24 h urine samples over 5 days following an oral 100 mg dose of DMI. Mean total clearance of DMI ( CLDMI ) from plasma was significantly… CONTINUE READING
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