Desipramine Modulation of α-, γ-Synuclein, and the Norepinephrine Transporter in an Animal Model of Depression

@article{Jeannotte2009DesipramineMO,
  title={Desipramine Modulation of α-, γ-Synuclein, and the Norepinephrine Transporter in an Animal Model of Depression},
  author={Alexis M. Jeannotte and John G. McCarthy and Eva E Redei and Anita Sidhu},
  journal={Neuropsychopharmacology},
  year={2009},
  volume={34},
  pages={987-998}
}
The mechanisms underlying depression remain elusive. We previously determined that α-synuclein (α-Syn) modulates the activity and trafficking of the norepinephrine transporter (NET) in a manner that is dependent on its interactions with microtubules (MTs). Here we sought to determine if α-Syn, or the other synuclein family members, β-synuclein (β-Syn) and γ-synuclein (γ-Syn), modulate NET activity in an animal model of depression, the Wistar–Kyoto (WKY) rat. The NET-selective antidepressant… CONTINUE READING
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