Designs of drug-combination phase I trials in oncology: a systematic review of the literature.

@article{Riviere2015DesignsOD,
  title={Designs of drug-combination phase I trials in oncology: a systematic review of the literature.},
  author={M-K Riviere and Christophe Le Tourneau and Xavier Paoletti and F. Dubois and Sarah Zohar},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2015},
  volume={26 4},
  pages={669-74}
}
BACKGROUND Combining several anticancer agents can increase the overall antitumor action, but at the same time, it can also increase the overall observed toxicity. Adaptive dose-escalation designs for drug combinations have recently emerged as an attractive alternative to algorithm-based designs, and they seem more effective in combination recommendations. These methods are not used in practice currently. Our aim is to describe international scientific practices in the setting of phase I drug… CONTINUE READING