Designing unconventional Fmoc-peptide-based biomaterials: structure and related properties.

@article{Chronopoulou2014DesigningUF,
  title={Designing unconventional Fmoc-peptide-based biomaterials: structure and related properties.},
  author={Laura Chronopoulou and Simona Sennato and Federico Bordi and Domenico Giannella and Antonio Di Nitto and Andrea Barbetta and Mariella Dentini and Anna Rita Togna and Giuseppina Ines Togna and Sabina Moschini and Cleofe Palocci},
  journal={Soft matter},
  year={2014},
  volume={10 12},
  pages={1944-52}
}
We have recently employed L-amino acids in the lipase-catalyzed biofabrication of a class of self-assembling Fmoc-peptides that form 3-dimensional nanofiber scaffolds. Here we report that using d-amino acids, the homochiral self-assembling peptide Fmoc-D-Phe3 (Fmoc-F*F*F*) also forms a 3-dimensional nanofiber scaffold that is substantially distinguishable from its L-peptide and heterochiral peptide (F*FF and FF*F*) counterparts on the basis of their physico-chemical properties. Such chiral… CONTINUE READING