Designing the Sniper: Improving Targeted Human Cytolytic Fusion Proteins for Anti-Cancer Therapy via Molecular Simulation

@inproceedings{Bochicchio2017DesigningTS,
  title={Designing the Sniper: Improving Targeted Human Cytolytic Fusion Proteins for Anti-Cancer Therapy via Molecular Simulation},
  author={Anna Bochicchio and Sandra Jordaan and Valeria Losasso and Shivan Chetty and Rodrigo Casasnovas Perera and Emiliano Ippoliti and Stefan Barth and Paolo Carloni},
  booktitle={Biomedicines},
  year={2017}
}
Targeted human cytolytic fusion proteins (hCFPs) are humanized immunotoxins for selective treatment of different diseases including cancer. They are composed of a ligand specifically binding to target cells genetically linked to a human apoptosis-inducing enzyme. hCFPs target cancer cells via an antibody or derivative (scFv) specifically binding to e.g., tumor associated antigens (TAAs). After internalization and translocation of the enzyme from endocytosed endosomes, the human enzymes… CONTINUE READING
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