Designing targeted ultrasound contrast for molecular imaging of secreted frizzled related protein-2 (SFRP2) without biotin-avidin linkages

@article{Tsuruta2017DesigningTU,
  title={Designing targeted ultrasound contrast for molecular imaging of secreted frizzled related protein-2 (SFRP2) without biotin-avidin linkages},
  author={James K. Tsuruta and Nancy Klauber-DeMore and Paul A. Dayton},
  journal={2017 IEEE International Ultrasonics Symposium (IUS)},
  year={2017},
  pages={1-1}
}
Clinical translation of targeted contrast agents for molecular imaging of disease precludes the use of the biotin-avidin cross linking strategy due to the immunogenicity of avidin. Our objective was to cross link targeting ligands to ultrasound contrast using non-immunogenic covalent chemistry, and to validate the resulting targeted contrast agents using a… CONTINUE READING