Designing synthetic RNAs to determine the relevance of structural motifs in picornavirus IRES elements.

Abstract

The function of Internal Ribosome Entry Site (IRES) elements is intimately linked to their RNA structure. Viral IRES elements are organized in modular domains consisting of one or more stem-loops that harbor conserved RNA motifs critical for internal initiation of translation. A conserved motif is the pyrimidine-tract located upstream of the functional… (More)
DOI: 10.1038/srep24243

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