Designing small, nonsugar activators of antithrombin using hydropathic interaction analyses.

@article{Gunnarsson2002DesigningSN,
  title={Designing small, nonsugar activators of antithrombin using hydropathic interaction analyses.},
  author={Gunnar Th. Gunnarsson and Umesh R. Desai},
  journal={Journal of medicinal chemistry},
  year={2002},
  volume={45 6},
  pages={1233-43}
}
Conformational activation of antithrombin is a critical mechanism for the inhibition of factor Xa, a proteinase of the blood coagulation cascade, and is typically achieved with heparin, a polyanionic polysaccharide clinically used for anticoagulation. Although numerous efforts have been directed toward the design of better activators, a fundamental tenet of these studies has been the assumed requirement of an oligo- or a polysaccharide backbone. We demonstrate here a concept that small… CONTINUE READING

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An active heparinoid obtained by sulphation of a galactomannan extracted from the endosperm of Senna macranthera seeds

  • L. Pires, P.A.J. Gorin, F. Reicher, M.-R. Sierakowski
  • Carbohydr. Polym
  • 2001

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