Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide

  title={Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide},
  author={Dianne S. Schwarz and Hongliu Ding and Lori A. Kennington and Jessica T Moore and Janell M. Schelter and Julja Burchard and Peter S. Linsley and Neil Aronin and Zuoshang Xu and Phillip D. Zamore},
  journal={PLoS Genetics},
  pages={293 - 296}
Small interfering RNAs (siRNAs), the guides that direct RNA interference (RNAi), provide a powerful tool to reduce the expression of a single gene in human cells. Ideally, dominant, gain-of-function human diseases could be treated using siRNAs that specifically silence the mutant disease allele, while leaving expression of the wild-type allele unperturbed. Previous reports suggest that siRNAs can be designed with single nucleotide specificity, but no rational basis for the design of siRNAs with… CONTINUE READING
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