Designing peptide receptor agonists and antagonists

@article{Hruby2002DesigningPR,
  title={Designing peptide receptor agonists and antagonists},
  author={Victor J. Hruby},
  journal={Nature Reviews Drug Discovery},
  year={2002},
  volume={1},
  pages={847-858}
}
The most ubiquitous mode for controlling and modulating cellular function, intercellular communication, immune response and information-transduction pathways is through peptide–protein non-covalent interactions. Hormones, neurotransmitters, antigens, cytokines and growth factors represent key classes of such peptide ligands. These ligands might either be processed fragments of larger precursor proteins or surface segments of larger proteins. Although there are numerous exceptions, such as… CONTINUE READING

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