Designing nanotopographical density of extracellular matrix for controlled morphology and function of human mesenchymal stem cells.


Inspired by ultrastructural analysis of ex vivo human tissues as well as the physiological importance of structural density, we fabricated nanogrooves with 1:1, 1:3, and 1:5 spacing ratio (width:spacing, width = 550 nm). In response to the nanotopographical density, the adhesion, migration, and differentiation of human mesenchymal stem cells (hMSCs) were… (More)
DOI: 10.1038/srep03552


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