Designing cytokine variants by phage-display.

  title={Designing cytokine variants by phage-display.},
  author={Heidi Schooltink and Stefan Rose-John},
  journal={Combinatorial chemistry & high throughput screening},
  volume={8 2},
Cytokines are important mediators of many cellular functions including coordination of the immune system and regulation of regenerative processes. Therefore, cytokines can be exploited for therapeutic strategies. Cytokines can be altered in a way that their biologic activity is enhanced or antagonized. This can be accomplished by changing the interaction of cytokines with their cognate cytokine receptor complexes. Therefore, many research groups tried to design cytokines, which bind with higher… CONTINUE READING

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