Designing combinatorial library mixtures using a genetic algorithm.

  title={Designing combinatorial library mixtures using a genetic algorithm.},
  author={Robert D. Brown and Yvonne C. Martin},
  journal={Journal of medicinal chemistry},
  volume={40 15},
The design of combinatorial mixture libraries should take account of a number of factors. This paper describes the application of a genetic algorithm to optimizing the diversity of libraries while minimizing the effort that will be needed to deconvolute the biological hits by mass-spectroscopic techniques. It differs from previous applications of genetic algorithms to combinatorial library design in that each chromosome encodes an entire library with the result that properties of the library… CONTINUE READING

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