Designing clinical trials in canine spinal cord injury as a model to translate successful laboratory interventions into clinical practice.

@article{Jeffery2011DesigningCT,
  title={Designing clinical trials in canine spinal cord injury as a model to translate successful laboratory interventions into clinical practice.},
  author={Nicholas D. Jeffery and Lindsay Hamilton and Nicolas Granger},
  journal={The Veterinary record},
  year={2011},
  volume={168 4},
  pages={102-7}
}
Many interventions have been shown to improve outcome after experimental spinal cord injury in laboratory animals. The challenge now is to determine whether any of these can be translated to become an efficacious therapy for clinical lesions - a process that is often difficult and frequently fails. Here, we discuss the steps that are required to make this transition and the need for rigorous clinical trials. A key component is an outcome measure that is amenable to statistical analysis; we… CONTINUE READING

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