Designing clinical trials for NOTES.

  title={Designing clinical trials for NOTES.},
  author={Joseph Romagnuolo and Peter B. Cotton},
  journal={Gastrointestinal endoscopy clinics of North America},
  volume={18 2},
  pages={371-85; xi}
This article breaks down the elements of designing clinical trials, with an emphasis on randomized controlled trials, as applied to advancing natural orifice translumenal endoscopic surgery research. It discusses research ethics, feasibility, design elements (such as randomization, blinding, and choosing a primary outcome), and issues regarding presentation… CONTINUE READING