Designing chemically modified oligonucleotides for targeted gene silencing.

  title={Designing chemically modified oligonucleotides for targeted gene silencing.},
  author={G. F. Deleavey and M. Damha},
  journal={Chemistry & biology},
  volume={19 8},
  • G. F. Deleavey, M. Damha
  • Published 2012
  • Biology, Medicine
  • Chemistry & biology
  • Oligonucleotides (ONs), and their chemically modified mimics, are now routinely used in the laboratory as a means to control the expression of fundamentally interesting or therapeutically relevant genes. ONs are also under active investigation in the clinic, with many expressing cautious optimism that at least some ON-based therapies will succeed in the coming years. In this review, we will discuss several classes of ONs used for controlling gene expression, with an emphasis on antisense ONs… CONTINUE READING
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