Designing a pilot sequential multiple assignment randomized trial for developing an adaptive treatment strategy.

@article{Almirall2012DesigningAP,
  title={Designing a pilot sequential multiple assignment randomized trial for developing an adaptive treatment strategy.},
  author={Daniel Almirall and Scott N. Compton and Meredith Gunlicks-Stoessel and Naihua Duan and Susan A. Murphy},
  journal={Statistics in medicine},
  year={2012},
  volume={31 17},
  pages={1887-902}
}
There is growing interest in how best to adapt and readapt treatments to individuals to maximize clinical benefit. In response, adaptive treatment strategies (ATS), which operationalize adaptive, sequential clinical decision making, have been developed. From a patient's perspective an ATS is a sequence of treatments, each individualized to the patient's evolving health status. From a clinician's perspective, an ATS is a sequence of decision rules that input the patient's current health status… CONTINUE READING