Designing a new generation of antidepressant drugs.

  title={Designing a new generation of antidepressant drugs.},
  author={Roger M. Pinder},
  journal={Acta psychiatrica Scandinavica. Supplementum},
  • Roger M. Pinder
  • Published 1997 in Acta psychiatrica Scandinavica. Supplementum
Although longer-term adaptive changes in receptor sensitivity may better explain the delayed onset of action of antidepressants, the mechanism based on acutely elevated noradrenaline (NA) and serotonin (5-HT) synaptic levels remains the basis for new drug design. The dual action concept, which postulates that effects on both NA and 5-HT are more advantageous than a selective action on serotonin reuptake (SSRI), has been used to design new antidepressants such as venlafaxine and mirtazapine… CONTINUE READING

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