Designing a new generation of anti-hCG vaccines for cancer therapy.

  title={Designing a new generation of anti-hCG vaccines for cancer therapy.},
  author={Peter J. Delves and Ray Kruse Iles and Ivan M. Roitt and Troy Lund},
  journal={Molecular and cellular endocrinology},
The heterodimeric 'pregnancy-specific' hormone human chorionic gonadotropin (hCG) has been used as the basis for a contraceptive vaccine. More recently, the observation that hCG, particularly in the form of the beta-chain expressed in the absence of alpha-chain, is aberrantly expressed in a number of different tumors has opened up a second potential application for such vaccines. Drawbacks of the currently available vaccines are that they are either relatively weakly immunogenic or that they… CONTINUE READING

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