Designing a large prevention trial: statistical issues.

@article{Kryscio2004DesigningAL,
  title={Designing a large prevention trial: statistical issues.},
  author={Richard J. Kryscio and Marta S. Mendiondo and Frederick A. Schmitt and William R. Markesbery},
  journal={Statistics in medicine},
  year={2004},
  volume={23 2},
  pages={
          285-96
        }
}
Recent research in Alzheimer's disease (AD) is centred about the early detection and prevention of this disease. Several recent moderate size clinical trials targeted at high risk cohorts have been designed along this theme. There have been few attempts to design a large trial to prevent this disease in elderly individuals at low risk for the disease. The purpose of this paper is to suggest a framework for designing a simple, large AD prevention trial. This framework uses a discrete time hazard… CONTINUE READING
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