Designing a fibrotic microenvironment to investigate changes in human liver sinusoidal endothelial cell function.

@article{Ford2015DesigningAF,
  title={Designing a fibrotic microenvironment to investigate changes in human liver sinusoidal endothelial cell function.},
  author={Andrew John Ford and Gaurav Jain and Padmavathy Rajagopalan},
  journal={Acta biomaterialia},
  year={2015},
  volume={24},
  pages={
          220-7
        }
}
The deposition of extracellular matrix (ECM) proteins by hepatic cells during fibrosis leads to the stiffening of the organ and perturbed cellular functions. Changes in the elasticity of liver tissue are manifested by altered phenotype in hepatic cells. We have investigated changes in human liver sinusoidal endothelial cells (hLSECs) that occur as the elastic modulus of their matrix transitions from healthy (6kPa) to fibrotic (36kPa) conditions. We have also investigated the role played by… CONTINUE READING

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