Designing Template-Free Predictor for Targeting Protein-Ligand Binding Sites with Classifier Ensemble and Spatial Clustering

@article{Yu2013DesigningTP,
  title={Designing Template-Free Predictor for Targeting Protein-Ligand Binding Sites with Classifier Ensemble and Spatial Clustering},
  author={Dong-Jun Yu and Jun Hu and Jing Yang and Hong-Bin Shen and Jinhui Tang and Jingyu Yang},
  journal={IEEE/ACM Transactions on Computational Biology and Bioinformatics},
  year={2013},
  volume={10},
  pages={994-1008}
}
Accurately identifying the protein-ligand binding sites or pockets is of significant importance for both protein function analysis and drug design. Although much progress has been made, challenges remain, especially when the 3D structures of target proteins are not available or no homology templates can be found in the library, where the template-based methods are hard to be applied. In this paper, we report a new ligand-specific template-free predictor called TargetS for targeting protein… CONTINUE READING

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