Designing Anti-inflammatory Drugs from Parasitic Worms: A Synthetic Small Molecule Analogue of the Acanthocheilonema viteae Product ES-62 Prevents Development of Collagen-Induced Arthritis

@inproceedings{AlRiyami2013DesigningAD,
  title={Designing Anti-inflammatory
Drugs from Parasitic Worms:
A Synthetic Small Molecule Analogue of the Acanthocheilonema
viteae Product ES-62 Prevents Development of Collagen-Induced
Arthritis},
  author={Lamyaa Al-Riyami and Miguel Angel Pineda and Justyna Rzepecka and Judith K. Huggan and Abedawn Ibrahim Khalaf and Colin J. Suckling and Fraser J Scott and David T. Rodgers and Margaret M Harnett and W Harnett},
  booktitle={Journal of medicinal chemistry},
  year={2013}
}
In spite of increasing evidence that parasitic worms may protect humans from developing allergic and autoimmune diseases and the continuing identification of defined helminth-derived immunomodulatory molecules, to date no new anti-inflammatory drugs have been developed from these organisms. We have approached this matter in a novel manner by synthesizing a library of drug-like small molecules based upon phosphorylcholine, the active moiety of the anti-inflammatory Acanthocheilonema viteae… CONTINUE READING
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