Designer probiotics for prevention of enteric infections

  title={Designer probiotics for prevention of enteric infections},
  author={Adrienne W Paton and Renato Morona and James C Paton},
  journal={Nature Reviews Microbiology},
Many microbial pathogens, including those responsible for major enteric infections, exploit oligosaccharides that are displayed on the surface of host cells as receptors for toxins and adhesins. Blocking crucial ligand–receptor interactions is therefore a promising therapeutic strategy. One approach is to express molecular mimics of host receptors on the surface of harmless recombinant bacteria that can survive in the gut. These 'designer probiotics' bind bacterial toxins in the gut lumen with… CONTINUE READING
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