Designer-Rekombinasen für präzises Genome Editing


Site-specific recombinases have long been used as powerful research tools to engineer the genome of model organisms. We have expanded the utility of recombinases by re-directing their DNA binding specificity to predefined target sequences naturally occurring in the genome of HIV-1. In contrast to programmable nucleases, such designer recombinases possess… (More)
DOI: 10.1007/s12268-017-0780-x