Designer Peptide and Protein Dendrimers: A Cross-Sectional Analysis.

@article{Sapra2019DesignerPA,
  title={Designer Peptide and Protein Dendrimers: A Cross-Sectional Analysis.},
  author={Rachit Sapra and Ram P. Verma and Govind P Maurya and Sameer Dhawan and Jisha Babu and V. Haridas},
  journal={Chemical reviews},
  year={2019}
}
Dendrimers have attracted immense interest in science and technology due to their unique chemical structure that offers a myriad of opportunities for researchers. Dendritic design allows us to present peptides in a branched three-dimensional fashion that eventually leads to a globular shape, thus mimicking globular proteins. Peptide dendrimers, unlike other classes of dendrimers, have immense applications in biomedical research due to their biological origin. The diversity of potential building… 

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References

SHOWING 1-10 OF 186 REFERENCES

Simplifying the synthesis of dendrimers: accelerated approaches.

A special focus capitalizes on the impact of the click chemistry concept on dendrimer synthesis and the promise it has to successfully accomplish highly sophisticated d endrimers, both traditional as well as heterofunctional, in a minimum number of chemical steps.

Peptide and glycopeptide dendrimer apple trees as enzyme models and for biomedical applications.

Solid phase peptide synthesis (SPPS) provides peptides with a dendritic topology when diamino acids are introduced in the sequences demonstrating the importance of the "apple tree" configuration for protein-like function in peptide dendrimers.

Peptide dendrimers: drug/gene delivery and other approaches

It is worth emphasizing that some peptide dendrimers show activity per se, with the use of targeting peptides or other specific groups that direct the drug/bioactive compounds to specific organs is an important trend in the search for better drug delivery systems.

Dendrimers in drug research.

Dendrimers are versatile, derivatisable, well-defined, compartmentalised chemical polymers with sizes and physicochemical properties resembling those of biomolecules e.g. proteins that may be used as drugs for antibacterial and antiviral treatment and have found use as antitumor agents.

Designer Peptide Dendrons and Dendrimers Based Soft Materials Through Self‐Assembly

A series of new aspartic and glutamic acid based peptide dendrons and dendrimers were designed and synthesized. The supramolecular assembly of these novel molecules were studied by scanning electron

Dendrimers in gene delivery.

Noncovalent synthesis of protein dendrimers.

The noncovalent synthetic strategy presented here provides access to well-defined, dynamic, semisynthetic protein assemblies in high yield and is therefore of interest to the field of nanomedicine as well as biomaterials.

One-component gels based on peptidic dendrimers: dendritic effects on materials properties.

Dendritic functionalization provides a useful way of tuning gel-phase materials properties, with clear dendritic effects on gel formation being quantified for the first time, illustrating the way dendrite functionalization can play a positive role in the formation of highly functional organic materials with desirable properties.

New-generation biomedical materials: Peptide dendrimers and their application in biomedicine

This review focuses on the development of peptide dendrimers with emphasis on their applications both in diagnostics and in therapy.

Peptide-Decorated Dendrimers and Their Bioapplications.

This Minireview highlights the development of PDDs driven by significantly improved ligation chemistry incorporating structurally well-defined peptides and the emerging use ofPDDs in imaging and drug development.
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