Designer Peptide and Protein Dendrimers: A Cross-Sectional Analysis.

  title={Designer Peptide and Protein Dendrimers: A Cross-Sectional Analysis.},
  author={Rachit Sapra and Ram P. Verma and Govind P Maurya and Sameer Dhawan and Jisha Babu and V. Haridas},
  journal={Chemical reviews},
Dendrimers have attracted immense interest in science and technology due to their unique chemical structure that offers a myriad of opportunities for researchers. Dendritic design allows us to present peptides in a branched three-dimensional fashion that eventually leads to a globular shape, thus mimicking globular proteins. Peptide dendrimers, unlike other classes of dendrimers, have immense applications in biomedical research due to their biological origin. The diversity of potential building… 

Molecular level precision and high molecular weight peptide dendrimers for drug-specific delivery.

The facile and liquid-phase synthesis of molecular level precision and amino-acid built-in polylysine (PLL) dendrimers with molecular weights as high as ∼60 kDa are reported, which showed potent antitumor activity against multiple cancer cell lines.

Tailoring of Peptide Vesicles: A Bottom-Up Chemical Approach.

  • V. Haridas
  • Chemistry, Biology
    Accounts of chemical research
  • 2021
This account provides advances made from the laboratory toward designing and understanding the mechanism of formation of spherical vesicular assembly, and highlights the progress made toward a heuristic approach to the de novo design of vesicles using pseudopeptides as building blocks.

Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides

The findings demonstrate the potential of lipid-conjugated, D-amino acid-containing peptide dendrimers to be utilized as an effective and safe delivery vector for splice-switching ONs.

Functional DNA-based hydrogel intelligent materials for biomedical applications.

This review summarizes the current state of DNA nanostructures, especially the intelligent DNA-based hydrogel materials, and focuses on design and engineering for bio-responsive use and proposes some reasonable prospects for the future development of intelligent DNA.

The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties

This account surveys early experiments confirming the inextricable influence of dendrimer branch cell symmetry on interior packing properties, first examples of Category (I) based UME behavior, nuclear magnetic resonance (NMR) protocols for systematic encapsulation characterization, application of these principles to the solubilization of active approved drugs and nanomedical applications.

Design, Synthesis and Activity of New N1-Alkyl Tryptophan Functionalized Dendrimeric Peptides against Glioblastoma

Novel polyfunctional peptide-based dendrimers covalently attached to N1-alkyl tryptophan (Trp) residues showed varying toxicity to NHA, while all were toxic to GBM cells.



Simplifying the synthesis of dendrimers: accelerated approaches.

A special focus capitalizes on the impact of the click chemistry concept on dendrimer synthesis and the promise it has to successfully accomplish highly sophisticated d endrimers, both traditional as well as heterofunctional, in a minimum number of chemical steps.

Peptide and glycopeptide dendrimer apple trees as enzyme models and for biomedical applications.

Solid phase peptide synthesis (SPPS) provides peptides with a dendritic topology when diamino acids are introduced in the sequences demonstrating the importance of the "apple tree" configuration for protein-like function in peptide dendrimers.

Peptide dendrimers: drug/gene delivery and other approaches

It is worth emphasizing that some peptide dendrimers show activity per se, with the use of targeting peptides or other specific groups that direct the drug/bioactive compounds to specific organs is an important trend in the search for better drug delivery systems.

Dendrimers in drug research.

Dendrimers are versatile, derivatisable, well-defined, compartmentalised chemical polymers with sizes and physicochemical properties resembling those of biomolecules e.g. proteins that may be used as drugs for antibacterial and antiviral treatment and have found use as antitumor agents.

Designer Peptide Dendrons and Dendrimers Based Soft Materials Through Self‐Assembly

A series of new aspartic and glutamic acid based peptide dendrons and dendrimers were designed and synthesized. The supramolecular assembly of these novel molecules were studied by scanning electron

Dendrimers in gene delivery.

Noncovalent synthesis of protein dendrimers.

The noncovalent synthetic strategy presented here provides access to well-defined, dynamic, semisynthetic protein assemblies in high yield and is therefore of interest to the field of nanomedicine as well as biomaterials.

One-component gels based on peptidic dendrimers: dendritic effects on materials properties.

Dendritic functionalization provides a useful way of tuning gel-phase materials properties, with clear dendritic effects on gel formation being quantified for the first time, illustrating the way dendrite functionalization can play a positive role in the formation of highly functional organic materials with desirable properties.

New-generation biomedical materials: Peptide dendrimers and their application in biomedicine

This review focuses on the development of peptide dendrimers with emphasis on their applications both in diagnostics and in therapy.

Peptide-Decorated Dendrimers and Their Bioapplications.

This Minireview highlights the development of PDDs driven by significantly improved ligation chemistry incorporating structurally well-defined peptides and the emerging use ofPDDs in imaging and drug development.