Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors.

Abstract

A series of 2-anilinobenzamide derivatives were designed, synthesized and evaluated for their SIRT1-inhibitory activity. Among these, compounds 3 and 5 inhibited SIRT1 activity in enzyme assays and suppressed the growth of Daudi and HCT116 cells.

DOI: 10.1016/j.bmc.2009.07.001

Cite this paper

@article{Suzuki2009DesignSE, title={Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors.}, author={Takayoshi Suzuki and Keiko Imai and Erika Imai and Shinsuke Iida and Ryuzo Ueda and Hiroki Tsumoto and Hidehiko Nakagawa and Naoki Miyata}, journal={Bioorganic & medicinal chemistry}, year={2009}, volume={17 16}, pages={5900-5} }