Design principles of adaptive immune systems

@article{Boehm2011DesignPO,
  title={Design principles of adaptive immune systems},
  author={Thomas Boehm},
  journal={Nature Reviews Immunology},
  year={2011},
  volume={11},
  pages={307-317}
}
  • T. Boehm
  • Published 1 May 2011
  • Biology
  • Nature Reviews Immunology
Both jawless vertebrates, such as lampreys and hagfish, and jawed vertebrates (encompassing species as diverse as sharks and humans) have an adaptive immune system that is based on somatically diversified and clonally expressed antigen receptors. Although the molecular nature of the antigen receptors and the mechanisms of their assembly are different, recent findings suggest that the general design principles underlying the two adaptive immune systems are surprisingly similar. The… 

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References

SHOWING 1-10 OF 108 REFERENCES

A thymus candidate in lampreys

Immunologists and evolutionary biologists have been debating the nature of the immune system of jawless vertebrates—lampreys and hagfish—since the nineteenth century. In the past 50 years, these fish

IgT, a primitive immunoglobulin class specialized in mucosal immunity

TLDR
It is shown that IgT, an immunoglobulin isotype of unknown function, acts like a mucosal antibody, and detected responses of rainbow trout IgT to an intestinal parasite only in the gut, whereas IgM responses were confined to the serum.

Origin and evolution of the adaptive immune system: genetic events and selective pressures

TLDR
Insight is offered into the latest advances in this field of adaptive immune system research and speculate on the selective pressures that led to the emergence and maintenance of the AIS.

Meeting the Demand for Innate and Adaptive Immunities During Evolution

TLDR
The adaptive immunity of vertebrates with lymphocytes and their specific receptors of the immunoglobulin superfamily, the major histocompatibility complex, developed from innate immunity evolutionary lines that can be traced back in earlier deuterostomes.

The MHC Molecules of Nonmammalian Vertebrates

TLDR
There is no molecular evidence yet to decide whether vertebrate immune systems (and particularly the MHC molecules) are evolutionarily related to invertebrate allorecognition systems, and the functional evidence can be interpreted either way.

Antibody responses of variable lymphocyte receptors in the lamprey

TLDR
The VLRB-bearing lineage of lymphocytes in sea lampreys is described, which responded to repetitive carbohydrate or protein determinants on bacteria or mammalian cells with lymphoblastoid transformation, proliferation and differentiation into plasmacytes that secreted multimeric antigen-specific VL RB antibodies.
...