Design principles of adaptive immune systems

  title={Design principles of adaptive immune systems},
  author={Thomas Boehm},
  journal={Nature Reviews Immunology},
  • T. Boehm
  • Published 1 May 2011
  • Biology
  • Nature Reviews Immunology
Both jawless vertebrates, such as lampreys and hagfish, and jawed vertebrates (encompassing species as diverse as sharks and humans) have an adaptive immune system that is based on somatically diversified and clonally expressed antigen receptors. Although the molecular nature of the antigen receptors and the mechanisms of their assembly are different, recent findings suggest that the general design principles underlying the two adaptive immune systems are surprisingly similar. The… 

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The adaptive immunity of vertebrates with lymphocytes and their specific receptors of the immunoglobulin superfamily, the major histocompatibility complex, developed from innate immunity evolutionary lines that can be traced back in earlier deuterostomes.

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