Design principles for regulator gene expression in a repressible gene circuit.

@article{Wall2003DesignPF,
  title={Design principles for regulator gene expression in a repressible gene circuit.},
  author={Michael E. Wall and William S. Hlavacek and Michael A. Savageau},
  journal={Journal of molecular biology},
  year={2003},
  volume={332 4},
  pages={
          861-76
        }
}
We consider the design of a type of repressible gene circuit that is common in bacteria. In this type of circuit, a regulator protein acts to coordinately repress the expression of effector genes when a signal molecule with which it interacts is present. The regulator protein can also independently influence the expression of its own gene, such that regulator gene expression is repressible (like effector genes), constitutive, or inducible. Thus, a signal-directed change in the activity of the… CONTINUE READING
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