Design, power, and interpretation of studies in the standard murine model of ALS.

Abstract

Identification of SOD1 as the mutated protein in a significant subset of familial amyotrophic lateral sclerosis (FALS) cases has led to the generation of transgenic rodent models of autosomal dominant SOD1 FALS. Mice carrying 23 copies of the human SOD1(G93A) transgene are considered the standard model for FALS and ALS therapeutic studies. To date, there… (More)
DOI: 10.1080/17482960701856300

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@article{Scott2008DesignPA, title={Design, power, and interpretation of studies in the standard murine model of ALS.}, author={Sean Scott and Janice E. Kranz and Jeff A. Cole and John M. Lincecum and Kenneth L. Thompson and Nancy H. Kelly and Alan G Bostrom and Jill Theodoss and Bashar M Al-Nakhala and Fernando G. Vieira and Jeyanthi Ramasubbu and James Heywood}, journal={Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases}, year={2008}, volume={9 1}, pages={4-15} }