Design of triptorelin loaded nanospheres for transdermal iontophoretic administration.

  title={Design of triptorelin loaded nanospheres for transdermal iontophoretic administration.},
  author={Sara Nicoli and Patrizia Santi and Patrick Couvreur and Guy Couarraze and P. -E. Colombo and Elias Fattal},
  journal={International journal of pharmaceutics},
  volume={214 1-2},
Triptorelin is a decapeptide analog of luteinizing hormone releasing hormone, currently used for the treatment of sex-hormones dependents diseases. The aim of this work was to prepare triptorelin-loaded nanospheres useful for transdermal iontophoretic administration. Nanospheres were prepared with the double emulsion/solvent evaporation technique. The effect of three parameters on the encapsulation efficiency has been determined: the role of the pH of the internal and external aqueous phases… CONTINUE READING


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